Hepatoprotective and Antioxidant Effects of Ecbolium viride, Gendarussa vulgaris and Sphaeranthus amaranthoides in NASH Induced Hepatotoxicity in Albino Wister Rats
No Thumbnail Available
Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Parishodh Journal
Abstract
Non-alcoholic steatohepatitis (NASH) caused due to over-nutrition, decreased physical activity with disproportionate high-fat food intake, obesity, type II diabetes mellitus (T2DM), and the metabolic syndrome characterized by steatosis, lobular inflammation and progressive pericellular fibrosis. This hepatic disease cannot be remedied by chemicals its addition may lead to complication. Hence herbal drug is the possible remedy. The hepatoprotective effect of Ecbolium viride, Gendarussa vulgaris and Sphaeranthus amaranthoides were monitored by estimating the Triglycerides(TG),Total cholesterol(TC),Low density lipoprotein(LDL), High density lipoprotein (HDL), Aspartate transaminases (AST), Alanine transaminases (ALT), Alkaline phospatases (ALP), and Lactate dehydrogenases (LDH).Plant extracts singly or in combination at a dose of 2g/kg significantly prevented the increase in serum level inliver. Theantioxidant enzymes following D- Galactosamine and diet induced hepatoxicity in albino rats was reversed by plant extracts.
Description
Keywords
Ecbolium viride, Gendarussa vulgaris, Sphaeranthus amaranthoides, NASH, Hepatoprotection, D-Galactosamine.