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Browsing School of Education by Author "Dominic Ravichandran"

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    Alginate in Bone Tissue Engineering
    (ResearchGate, 2017-12) Dominic Ravichandran
    Regenerative medicine has witnessed a paradigm shift from synthetic implants and tissue grafts to a bone tissue engineering (BTE) approach that incorporates biodegradable bioceramic composite scaffolds with biological cells. Polysaccharides, a biodegradable naturally occurring polymer can be useful either as carriers systems for active biomolecules or as cell carriers. It plays a crucial role to mimic the natural extra cellular matrix (ECM) for the development of 3D scaffold material in BTE and regenerative medicine. Alginate, a natural polysaccharide acts a biodegradable gel when cross-linked with calcium ions. Further, it encapsulates and immobilizes a variety of cells for immunoisolatory and biochemical processing applications. The bone-forming osteoblast cells can easily be attached to the alginate surface and therefore can proliferate well. Hence, alginate is widely utilized in BTE for its bioavailability, biodegradability, and ease of access.
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    Chicken Bone as a Bioresource for the Bioceramic
    (Taylor & Francis, 2012-06-20) Dominic Ravichandran
    Natural hydroxyapatite (HAP) is isolated from waste chicken bone by thermal calcinations at different temperatures in the range of 200 ◦C to 1000 ◦C. The isolated HAP has been characterized using thermo gravimetric analysis (TG) and differential thermal analysis (DTA), Fourier Transformed Infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission electron microscope (FE-SEM), and energy dispersive X-ray (EDX). The XRD results showed that the enhanced crystallinity of HAP phase by thermal calcination above 600 ◦C and the crystal size has been found to increase with increasing temperature of thermal calcinations due to agglomeration. Value addition for the waste chicken bone is given by the isolation of useful bioceramics (HAP) and the optimum temperature for the thermal calcination is found to be 600 ◦C. The isolated HAP has been characterized as carbonated HAP of B type with the hexagonal structure.
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    Correlation and regression studies of water quality parameters: A case study of water from the Bhavani river
    (ResearchGate, 2007-07) Dominic Ravichandran
    In this paper, a calculation of correlation coefficient between various water quality parameters of Bhavani river is carried out. The analysis show significant linear relationship between pH, alkalinity, hardness, Ca 2+, Mg2+, concentration of F- and total solids. Finally, multiple regression equation relating hardness with other paramters is developed. The usefulness of correlation and implication of regression equations are discussed.
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    Covalent functionalization of single-walled carbon nanotubes with anthracene by green chemical approach and their temperature dependent magnetic and electrical conductivity studies
    (VIT University, 2013-10-15) Dominic Ravichandran
    Single-walled carbon nanotubes (SWCNTs) were covalently functionalized with anthracene in molten urea by a green chemical approach. The anthracene functionalized single-walled carbon nanotubes (Antf-SWCNTs) were examined along with SWCNTs, using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, powder X-Ray diffraction (XRD), and scanning, and transmission electron microscopy. The observations revealed the functionalization of SWCNTs by anthracene. The temperature dependent magnetization (300e5 K) and electrical resistivity were also measured for both SWCNTs and Ant-f-SWCNTs. The electrical resistivity of Ant-f-SWCNTs at 300 K was found to be 1.27 KUm, which is much lower than 388.55 KUm for pristine. This indicated a 300 fold increase in conductivity at room temperature for Ant-f-SWCNTs when compared to SWCNTs. The temperature dependence of the conductivity provided an indication of the semiconducting behaviour.
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    Marine Polysaccharide (Chitosan) and Its Derivatives as Water Purifier
    (ResearchGate, 2013-04) Dominic Ravichandran
    Chitosan (CH)-based biosorbents are by far the most extensively studied material among those suggested for water and wastewater treatment by biosorption. This is due to their ability to remove a wide range of pollutants and simpler ways to synthesize them [19][20][21][22]. CH is a cationic polymer, and its biosorbents can be held together either by physical interactions like hydrogen bonding, electrostatic interactions, Vander Waal's forces, or by chemical crosslinking by covalent bonds [12,[23][24][25][26][27]. ...
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    Synthesis and study the anti-proliferative effect of new series of 1H-imidazo[4,5-c]quinoline derivatives in MCF-7 (human breast cancer) cells
    (VIT University, 2015-06) Dominic Ravichandran
    Breast cancer is the most prevalent form of cancer in women world over. MCF-7 cells are useful for in vitro breast cancer studies because the cell line has retained several ideal characteristics particular to the mammary epithelium. These include the ability for MCF-7 cells to process estrogens, in the form of estuarial, via estrogens receptors in the cell cytoplasm. This makes the MCF-7 cell line an estrogens receptor (ER) positive control cell line. In breast cancer cells containing oestrogen receptors both oestrogens and growth factors can stimulate proliferation, invasion and the secretion of a number of proteins.