Diploma in Clinical Medicine

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    Introducing Psychology for Nurses and Healthcare Professionals
    (Pearson Education Limited, 2010) Dominic Upton
    What makes someone feel healthy? Why do some people respond differently under stress to others? Why don’t people always follow nursing advice? This second edition of Introducing Psychology for Nurses and Healthcare Professionalsprovides an accessible but thorough introduction to the key psychological theories and concepts which underpin nursing and healthcare, and clearly demonstrates how they can be applied in clinical practice. Using a research-led approach, each chapter guides you through important theories and topics in health psychology, such as lifespan and development, communication, and social processes, and helps you use your understanding to deliver better patient care.
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    The GC–MS analysis of the diethylether and ethylacetate fraction of the peel of Solanum incanum and the study of their antibacterial activity
    (Institute of Korean Medicine, Kyung Hee University, 2022) Ravichandran,Yetayih
    The diethyl ether and ethyl acetate fractions of the peel of the fruit of Solanum incanum. (S. incanum) were analyzed using gas chromatography-mass spectrometry (GC–MS). 105 compounds were identified in the diethyl ether fraction and 75 compounds were identified in ethyl acetate fraction. Among them, 5 compounds were analyzed by fragmentation pattern,discussed, and compared with NIST database. The antibacterial screening was also conducted for bothdiethyl ether and ethylacetate fractions of the fruit peel of S.incanum using four pathogens, two Gram-positive bacteria Staphylococcus aureus(S. aureus) and Streptococcus pyogenes (S. pyogenes) and two Gram negative bacteria Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumonia), at various concentrations (250, 500, 750 and 1000 μg/ml). The diethyl ether and ethyl acetate fractions of the peel of S. incanum exhibited activity against E. coli and K. pneumonia at 1000 μg/ml concentration.
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    Traditional Uses, Pharmacological Action and Phytochemical Analysis of Carissa carandas Linn:A Review
    (Natural Products Chemistry & Research, 2018) Tesfaye,Ravichadran
    Starting from immemorial time; peoples traditionally used herbs and plants to treat different human and animals ailments. This initiated scientists to investigate on traditional medicinal plants and herbs for biological activities by checking through bioassay and then isolating the bioactive constituents from biologically active medicinal plants and herbs. The different parts of Carissa carandas have been used for various human ailments. It has been used by traditional healers in the treatment of scabies, intestinal worms, pruritus, biliousness, snake-bite/poisoning,astringent, anemia, stomachache, diarrhea, rheumatism, earache, anthelmintic, female libido, hyperdipsia, anorexia,intermittent, mouth ulcer and sore throat, syphilitic pain, burning sensation fever, biliary dysfunction and also used as appetizer, antimicrobial, anti-fungal, analgesic, anti-inflammatory and anti-scorbutic. Its biological activities have been reported by different researchers as hepatoprotective, neuropharmacological, anticancer, antioxidant, anticonvulsant, antiulcer, anthelmintic, analgesic, anti-inflammatory, cardiovascular, antinociceptive, anti-diabetic,anti-pyretic, cardiotonic, histamine releasing, DNA damage inhibition, constipation, anti-diarrheal, antihyperlipidemic,antibacterial, antiviral, cytotoxic potential and diuretic. Its phytochemical constituents which impart medicinal value to the plant was reported as alkaloids, carbohydrates, glycosides, unsaturated sterols, phenolics, saponins, flavonoids, steroids, triterpenoids, tannins, proteins, cardiac glycosides, phytosterol, phlobatannins, leucoanthocyanin, chalcones, coumarin, anthracyanin, emodin, minerals acids, vitamins and anthraquinone glycosides. So far 14 compounds have been isolated from roots, 40 compounds from fruits and 19 compounds from leafs. These compounds include phenolic, alkaloids, sterols, terpenoids, simple acids, simple ester, sesquiterpenes, carboxylate, amino acids, glucose and galactose, sterols glycosides, phenolic lignin. Hence we reviewed the traditional uses, extraction methods, pharmacological uses and phytochemical constituents of Carissa carandas
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    Biomimetic Graphene Oxide-Xanthan Gum-Hydroxyapatite Composite Scaffold For Bone Tissue Engineering
    (The Tunisian Chemical Society and Springer Nature Switerland AG, 2022) Ravichadran,Vanpeene,Rajesh,Kuo,Gure
    Purpose In recent years, tissue engineering scaffolds have gained popularity as a replacement for metallic/synthetic implants and tissue grafts
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    A Review on Anticancer Activity of Some Plant-Derived Compounds and Their Mode of Action
    (Nat Prod Chem Re, 2018) Ravichadran,Tesfaye
    Cancer is a set of malignancies that has in common the aggravated and uncontrolled cellular growth, as well as the capacity of cellular invasion to different organs of the primary site. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival. Compounds of plant origin, including food components, have attracted scientific attention for use as agents for cancer prevention and treatment. Many pharmaceutical agents have been discovered by screening natural products from plants. The exploration into natural products offers great opportunity to evaluate new chemical classes of anticancer agents as well as study novel and potentially relevant mechanisms of action. The mechanisms of action of plant-derived anticancer drugs possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis that may be intrinsic or extrinsic. The present review summarizes the works so far conducted on this aspect with a view to provide a baseline information for promoting the plant-derived anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease